Transcriptional and epigenetic targets of MEF2C in human microglia contribute to cellular functions related to autism risk and age-related disease.
Nguyen C, Broersma EH, Warden AS, Mora C, Han CZ, Keulen Z, Spann N, Wang J, Ramirez G, Mak S, Trescott S, Khakpour M, Johnson A, Qureshi F, La Frano MR, Mohajeri K, Talkowski ME, Corradin O, Tremblay ME, Glass CK, Coufal NG.
Nature Immunology 2025 Nov
doi: 10.1038/s41590-025-02299-0 PMID: 41125877
The brain neurovascular epigenome and its association with dementia
Ziegler KC, Askarova A, Gergian C, Yaa RM, van Dalen JD, Transfeld JL, Zoppi F, Du J, Clode D, Rahbar F, Graham RE, Sargurupremraj M, Debette S, Gonda DD, Levy ML, Chandran S, Falk S, Karow M, Matthews PM, Coufal NG, Nott A.
Neuron 2025 Oct
doi: 10.1016/j.neuron.2025.10.002 PMID: 41173000​
The prototypical interferonopathy: Aicardi-Goutieres syndrome from bedside to bench
Hofer MJ, Modesti N, Coufal NG, Wang Q, Sase S, Miner JJ, Vanderver A, Bennett ML.
Immunol Reviews. 2024 Oct
doi: 10.1111/imr.13413. PMID: 39473130 
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain
Chen J, Crouch EE, Zawadzki ME, Jacobs KA, Mayo LN, Choi JJ, Lin PY, Shaikh S, Tsui J, Gonzalez-Granero S, Waller S, Kelekar A, Kang G, Valenzuela EJ, Birrueta JO, Diafos LN, Wedderburn-Pugh K, Di Marco B, Xia W, Han CZ, Coufal NG, Glass CK, Fancy SPJ, Alfonso J, Kriegstein AR, Oldham MC, Garcia-Verdugo JM, Kutys ML, Lehtinen MK, Combes AJ, Huang EJ.
Nature Neuroscience. 2024 Nov
doi: 10.1038/s41593-024-01769-2. PMID: 39349662 
Microglial lipid droplet accumulation in tauopathy brains is regulated by neuronal AMPK
Li Y, Munoz-Mayorga D, Nie Y, Kang N, Tao Y, Lagerwall J, Pernaci C, Curtin G, Coufal NG, Mertens J, Shi L, Chen X
Cell Metabolism. 2024 June 4
doi: 10.1016/j.cmet.2024.03.014. PMID: 38657612
The prototypical interferonopathy: Aicardi-Goutieres syndrome from bedside to bench
Hofer MJ, Modesti N, Coufal NG, Wang Q, Sase S, Miner JJ, Vanderver A, Bennett ML.
Immunology Reviews. 2024 Oct 29
doi: 10.1111/imr.13413. PMID: 39473130 
Gene editing improves endoplasmic reticulum mitochondrial contacts and unfolded protein response in Friedreich's ataxia iPSC-derived neurons
Mishra P, Sivakumar A, Johnson A, Pernaci C, Warden AS, El-Hachem LR, Hansen E, Badell-Grau RA, Khare V, Ramirez G, Gillette S, Solis AB, Guo P, Coufal NG*, Cherqui S*. 
Frontiers in Pharmacology. 2024 Feb 14.
doi: 10.3389/fphar.2024.1323491   PMID: 38420191
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK
Li Y, Munoz-Mayorga D, Nie Y, Kang N, Tao Y, Langerwall J, Pernaci C, Curtin G, Coufal NG, Mertens J, Shi L, Chen X. 
Cell Metabolism. 2024 Apr 16.
doi: 10.1016/j.cmet.2024.03.014   PMID: 38657612
Human microglia maturation is underpinned by specific gene regulatory networks
Han CZ, Li RZ, Han E, Trescott S, Fixsen BR, Nguyen CT, Mora CM, Spann NJ, Bennett HR, Poirion O, Buchanan J, Warden AS, Xia B, Schlachetzki JCM, Pasillas MP, Preissl S, Wang A, O'Connor C, Shriram S, Kim R, Schafer D, Ramirez G, Challacombe J, Anavim SA, Johnson A, Gupta M, Glass IA, BDRL, Levy ML, Ben Haim S, Gonda DD, Laurent L, Hughes JF, Page DC, Blurton-Jones M, Glass CK, Coufal NG. 
Immunology. 2023 August 8.
doi: 10.1016/j.immuni.2023.07.016  PMID: 37582369
Human microglial models to study host-virus interactions
McMillan RE, Wang E, Carlin AF, Coufal NG.  
Experimental Neurology. 2023 May
​doi: 10.1016/j.bbi.2022.10.008 PMID: 36336207
SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity. 
Fixsen BR, Han CZ, Zhou Y, Spann NJ, Saisan P, Shen Z, Balak C, Sakai M, Cobo I, Holtman IR, Warden AS, Ramirez G, Collier JG, Pasillas MP, Yu M, Hu R, Li B, Belhocine S, Gosselin D, Coufal NG, Ren B, Glass CK. 
Nature Immunology. 2023 June 15.
doi: 10.1038/s41590-023-01528-8  PMID: 37322178​
Dynamic activity in cis-regulatory elements of leukocytes identifies transcription factor activation and stratifies COVID-19 severity in ICU patients. 
Lam MTY, Tuttke S, Odish MF, Le HD, Hansen EA, Nguyen CT, Trescott S, Kim R, Deota S, Change MW, Patel A, Hepokoski M, Alotaibi M, Rolfsen M, Perofsky K, Warden AS, Foley J, Ramirez S, Dan JM, Abbott RK, Crotty S, Crotty Alexander LE, Malhotra A, Panda S, Benner CW, Coufal NG. 
Cell Reports Medicine. 2023 Feb 21; 4(2): 100935
 doi: 10.1016/j.xcrm.2023.100935  PMID 36758547
Tools for studying human microglia: In vitro and in vivo strategies
Warden AS, Han C, Hansen E, Trescott S, Nguyen C, Kim R, Schafer D, Johnson A, Wright M, Ramirez G, Lopez-Sanchez M, Coufal NG. 
Brain, Behavior, and Immunity. 2023 Jan; 107:369-382
 doi: 10.1016/j.bbi.2022.10.008  PMID 36336207
Gene regulatory networks underlying human microglia maturation
​Han CZ, Li RZ, Hansen E, Bennett HR, Poirion O, Buchanan J, Challacombe JF, Fixsen BR, Trescott S, Schlachetzki JCM, Preissl S, Wang A, O'Connor C, Warden AS, Shriram S, Kim R, Nguyen CT, SChafer DM, Ramirez G, Anavim SA, Johnson A, Sajti E, Gupta M, Levy ML, Ben-Haim S, Gonda DD, Laurent L, Glass CK, Coufal NG. 
bioRxiv. 2021
https://doi.org/10.1101/2021/06.02.446636
Brain cell type-specific enhancer-promoter interactome maps and disease - risk association
​Nott A*, Holtman IR*, Coufal NG*, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK. 
Science. 2019 Nov 29;366(6469):1134-1139.
doi: 10.1126/science.aay0793.  PMID 31727856
Development of a chimeric model to study and manipulate human microglia in vivo
Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, Davtyan H, Glass CK, Healy LM, Gandhi SP, Spitale RC, Blurton-Jones M. 
Neuron. 2019 Sep 25; 103(6):1016-1033.e10
 doi: 10.1016/j.neuron/2019.07.002. PMID 31375314
An environment-dependent transcriptional network specifies human microglia identity
Gosselin D*, Skola D*, Coufal NG*, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK. (*contributed equally)
Science. 2017 Jun 23; 356(6344): eaal3222 366
 doi: 10.1126/science.aal3222.  PMID 28546318
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