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Gene editing improves endoplasmic reticulum mitochondrial contacts and unfolded protein response in Friedreich's ataxia iPSC-derived neurons
Mishra P, Sivakumar A, Johnson A, Pernaci C, Warden AS, El-Hachem LR, Hansen E, Badell-Grau RA, Khare V, Ramirez G, Gillette S, Solis AB, Guo P, Coufal NG*, Cherqui S*. Frontiers in Pharmacology. 2024 Feb 14. doi: 10.3389/fphar.2024.1323491 PMID: 38420191 |
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Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK
Li Y, Munoz-Mayorga D, Nie Y, Kang N, Tao Y, Langerwall J, Pernaci C, Curtin G, Coufal NG, Mertens J, Shi L, Chen X. Cell Metabolism. 2024 Apr 16. doi: 10.1016/j.cmet.2024.03.014 PMID: 38657612 |
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Human microglia maturation is underpinned by specific gene regulatory networks
Han CZ, Li RZ, Han E, Trescott S, Fixsen BR, Nguyen CT, Mora CM, Spann NJ, Bennett HR, Poirion O, Buchanan J, Warden AS, Xia B, Schlachetzki JCM, Pasillas MP, Preissl S, Wang A, O'Connor C, Shriram S, Kim R, Schafer D, Ramirez G, Challacombe J, Anavim SA, Johnson A, Gupta M, Glass IA, BDRL, Levy ML, Ben Haim S, Gonda DD, Laurent L, Hughes JF, Page DC, Blurton-Jones M, Glass CK, Coufal NG. Immunology. 2023 August 8. doi: 10.1016/j.immuni.2023.07.016 PMID: 37582369 |
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Human microglial models to study host-virus interactions
McMillan RE, Wang E, Carlin AF, Coufal NG. Experimental Neurology. 2023 May doi: 10.1016/j.bbi.2022.10.008 PMID: 36336207 |
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SALL1 enforces microglia-specific DNA binding and function of SMADs to establish microglia identity.
Fixsen BR, Han CZ, Zhou Y, Spann NJ, Saisan P, Shen Z, Balak C, Sakai M, Cobo I, Holtman IR, Warden AS, Ramirez G, Collier JG, Pasillas MP, Yu M, Hu R, Li B, Belhocine S, Gosselin D, Coufal NG, Ren B, Glass CK. Nature Immunology. 2023 June 15. doi: 10.1038/s41590-023-01528-8 PMID: 37322178 |
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Dynamic activity in cis-regulatory elements of leukocytes identifies transcription factor activation and stratifies COVID-19 severity in ICU patients.
Lam MTY, Tuttke S, Odish MF, Le HD, Hansen EA, Nguyen CT, Trescott S, Kim R, Deota S, Change MW, Patel A, Hepokoski M, Alotaibi M, Rolfsen M, Perofsky K, Warden AS, Foley J, Ramirez S, Dan JM, Abbott RK, Crotty S, Crotty Alexander LE, Malhotra A, Panda S, Benner CW, Coufal NG. Cell Reports Medicine. 2023 Feb 21; 4(2): 100935 doi: 10.1016/j.xcrm.2023.100935 PMID 36758547 |
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Tools for studying human microglia: In vitro and in vivo strategies
Warden AS, Han C, Hansen E, Trescott S, Nguyen C, Kim R, Schafer D, Johnson A, Wright M, Ramirez G, Lopez-Sanchez M, Coufal NG. Brain, Behavior, and Immunity. 2023 Jan; 107:369-382 doi: 10.1016/j.bbi.2022.10.008 PMID 36336207 |
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Gene regulatory networks underlying human microglia maturation
Han CZ, Li RZ, Hansen E, Bennett HR, Poirion O, Buchanan J, Challacombe JF, Fixsen BR, Trescott S, Schlachetzki JCM, Preissl S, Wang A, O'Connor C, Warden AS, Shriram S, Kim R, Nguyen CT, SChafer DM, Ramirez G, Anavim SA, Johnson A, Sajti E, Gupta M, Levy ML, Ben-Haim S, Gonda DD, Laurent L, Glass CK, Coufal NG. bioRxiv. 2021 https://doi.org/10.1101/2021/06.02.446636 |
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Brain cell type-specific enhancer-promoter interactome maps and disease - risk association
Nott A*, Holtman IR*, Coufal NG*, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK. Science. 2019 Nov 29;366(6469):1134-1139. doi: 10.1126/science.aay0793. PMID 31727856 |
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Development of a chimeric model to study and manipulate human microglia in vivo
Hasselmann J, Coburn MA, England W, Figueroa Velez DX, Kiani Shabestari S, Tu CH, McQuade A, Kolahdouzan M, Echeverria K, Claes C, Nakayama T, Azevedo R, Coufal NG, Han CZ, Cummings BJ, Davtyan H, Glass CK, Healy LM, Gandhi SP, Spitale RC, Blurton-Jones M. Neuron. 2019 Sep 25; 103(6):1016-1033.e10 doi: 10.1016/j.neuron/2019.07.002. PMID 31375314 |
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An environment-dependent transcriptional network specifies human microglia identity
Gosselin D*, Skola D*, Coufal NG*, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK. (*contributed equally) Science. 2017 Jun 23; 356(6344): eaal3222 366 doi: 10.1126/science.aal3222. PMID 28546318 |
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